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Literature summary for 6.3.1.2 extracted from
- Glutamine synthetase and glutamine synthetase-like protein from human brain: purification and comparative characterization (2000), J. Neurochem., 75, 2574-2582.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required, less efficient than Mn2+ | Homo sapiens |  |
| Mn2+ | required, highest activity at 0.6-1 mM, higher concentrations inhibitory | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 44000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + glutamate + NH4+ | Homo sapiens | central enzyme of nitrogen metabolism | ADP + phosphate + L-glutamine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from frozen and non-frozen tissue | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + glutamate + NH4+ | - |
Homo sapiens | ADP + phosphate + L-glutamine | - |
r | |
| ATP + glutamate + NH4+ | central enzyme of nitrogen metabolism | Homo sapiens | ADP + phosphate + L-glutamine | - |
r | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | six isoforms with different pI | - |
6 |
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