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Literature summary for 6.3.1.13 extracted from

  • Vilcheze, C.; Av-Gay, Y.; Barnes, S.W.; Larsen, M.H.; Walker, J.R.; Glynne, R.J.; Jacobs, W.R.
    Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis (2011), Antimicrob. Agents Chemother., 55, 4422-4423.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
del D86 naturally occuring mutation, del bp 255-257, the mutant shows 6.9% activity compared to the wild-type Mycobacterium tuberculosis variant bovis
G54S naturally occuring mutation, inactive mutant Mycobacterium tuberculosis variant bovis
additional information mutant mc24980attB::pMV361::mshCBo shows 169% activity compared to the wild-type enzyme Mycobacterium tuberculosis variant bovis
P47R naturally occuring mutation, inactive mutant Mycobacterium tuberculosis variant bovis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis variant bovis
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gene mshC
-

Synonyms

Synonyms Comment Organism
MshC
-
Mycobacterium tuberculosis variant bovis

General Information

General Information Comment Organism
malfunction mutants defective in mycothiol biosynthesis show mutations in genes coding for the glycosyltransferase (mshA) or the cysteine ligase (mshC). These mutants show low-level resistance to isoniazid but are highly resistant to ethionamide, mutations in mycothiol biosynthesis genes may contribute to isoniazid or ethionamide resistance across mycobacterial species Mycobacterium tuberculosis variant bovis