Protein Variants | Comment | Organism |
---|---|---|
del D86 | naturally occuring mutation, del bp 255-257, the mutant shows 6.9% activity compared to the wild-type | Mycobacterium tuberculosis variant bovis |
G54S | naturally occuring mutation, inactive mutant | Mycobacterium tuberculosis variant bovis |
additional information | mutant mc24980attB::pMV361::mshCBo shows 169% activity compared to the wild-type enzyme | Mycobacterium tuberculosis variant bovis |
P47R | naturally occuring mutation, inactive mutant | Mycobacterium tuberculosis variant bovis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis variant bovis | - |
gene mshC | - |
Synonyms | Comment | Organism |
---|---|---|
MshC | - |
Mycobacterium tuberculosis variant bovis |
General Information | Comment | Organism |
---|---|---|
malfunction | mutants defective in mycothiol biosynthesis show mutations in genes coding for the glycosyltransferase (mshA) or the cysteine ligase (mshC). These mutants show low-level resistance to isoniazid but are highly resistant to ethionamide, mutations in mycothiol biosynthesis genes may contribute to isoniazid or ethionamide resistance across mycobacterial species | Mycobacterium tuberculosis variant bovis |