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Literature summary for 6.3.1.13 extracted from

  • Tremblay, L.W.; Fan, F.; Vetting, M.W.; Blanchard, J.S.
    The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway (2008), Biochemistry, 47, 13326-13335.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
incubation of the enzyme with the cysteinyl adenylate analogue, 5'-O-[N-(L-cysteinyl)-sulfamonyl]adenosine, followed by a 24 h limited trypsin proteolysis yields an enzyme preparation that readily crystallizes, 1.6 A crystal structure Mycolicibacterium smegmatis

Inhibitors

Inhibitors Comment Organism Structure
5'-O-[N-(L-cysteinyl)sulfamonyl]adenosine competitive inhibition Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mycolicibacterium smegmatis penultimate enzyme in the mycothiol biosynthetic pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information penultimate enzyme in the mycothiol biosynthetic pathway Mycolicibacterium smegmatis ?
-
?

Synonyms

Synonyms Comment Organism
MshC
-
Mycolicibacterium smegmatis