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Literature summary for 6.2.1.45 extracted from

  • Lu, X.; Malley, K.R.; Brenner, C.C.; Koroleva, O.; Korolev, S.; Downes, B.P.
    A MUB E2 structure reveals E1 selectivity between cognate ubiquitin E2s in eukaryotes (2016), Nat. Commun., 7, 12580 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.45

Cloned(Commentary)

Cloned (Comment) Organism
gene UBA1, sequence comparisons Arabidopsis thaliana
gene UBA2, sequence comparisons Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
AtMUB3 the MUB3 protein of Arabidopsis thaliana strongly reduces the E2-ubiquitin formation by E1. Inhibitory effects of wild-type and mutant MUB3 proteins, overview; the MUB3 protein of Arabidopsis thaliana strongly reduces the E2-ubiquitin formation by E1. Inhibitory effects of wild-type and mutant MUB3 proteins, overview Arabidopsis thaliana
additional information Arabidopsis thaliana MUBs1-6 interact specifically with the Arabidopsis thaliana group VI E2 family proteins, MUBs specifically inhibit activation of these critical Ub E2s; Arabidopsis thaliana MUBs1-6 interact specifically with the Arabidopsis thaliana group VI E2 family proteins, MUBs specifically inhibit activation of these critical Ub E2s Arabidopsis thaliana

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine Arabidopsis thaliana
-
 AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana P92974 UBA2
-
Arabidopsis thaliana P93028 UBA1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine
-
 Arabidopsis thaliana AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
AtUBA1
-
 Arabidopsis thaliana
AtUBA2
-
 Arabidopsis thaliana
E1
-
 Arabidopsis thaliana
Ub-activating enzyme
-
 Arabidopsis thaliana
Ubiquitin-activating enzyme
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
evolution MUB inhibition of E1 is conserved between plants and humans Arabidopsis thaliana
physiological function ubiquitin-activating enzyme (E1) activates ubiquitin (Ub) conjugating enzyme (E2) Arabidopsis thaliana