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Literature summary for 6.2.1.45 extracted from

  • Lao, T.; Chen, S.; Sang, N.
    Two mutations impair the stability and function of ubiquitin-activating enzyme (E1) (2012), J. Cell. Physiol., 227, 1451-1458.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
A189T the mutant enzyme is less stable than its wild-type counterpart, and restrictive temperature (39°C) accelerates its degradation Mus musculus
W714C the mutant enzyme is less stable than its wild-type counterpart, and restrictive temperature (39°C) accelerates its degradation Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
TS-20 cell
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
Ub-activating ligase
-
Mus musculus
Ubiquitin-activating enzyme E1 Mus musculus

General Information

General Information Comment Organism
malfunction defects in E1 cause apoptotic death of TS-20 cells Mus musculus