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Literature summary for 6.2.1.45 extracted from

  • Pelzer, C.; Kassner, I.; Matentzoglu, K.; Singh, R.K.; Wollscheid, H.P.; Scheffner, M.; Schmidtke, G.; Groettrup, M.
    UBE1L2, a novel E1 enzyme specific for ubiquitin (2007), J. Biol. Chem., 282, 23010-23014.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens UBE1L2 transfers activated ubiquitin onto UbcH5b and supports E3-mediated polyubiquitylation ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Homo sapiens A0AVT1
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
SW-60 cell colon carcinoma cell Homo sapiens
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testis the UBE1L2 mRNA is most abundantly expressed in the testis Mus musculus
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testis the UBE1L2 mRNA is most abundantly expressed in the testis Homo sapiens
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testis most abundant expression Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ubiquitin + [ubiquitin-activating protein Uba6]-L-cysteine isoform Uba6 forms a covalent link with ubiquitin in vitro and in vivo, which is sensitive to reducing conditions. Recombinant E1 enzyme Uba6 can activate ubiquitin and transfer it onto the ubiquitin-conjugating enzyme UbcH5B. Ubiquitin activated by Uba6 can be used for ubiquitylation of p53 and supports the autoubiquitylation of the E3 ubiquitin ligases HectH9 and E6-AP Homo sapiens AMP + diphosphate + [ubiquitin-activating protein Uba6]-S-ubiquitinyl-L-cysteine
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?
additional information UBE1L2 transfers activated ubiquitin onto UbcH5b and supports E3-mediated polyubiquitylation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Uba6
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Homo sapiens
UBE1L2
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Mus musculus
UBE1L2
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Homo sapiens
ubiquitin-activating enzyme 6
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Homo sapiens
ubiquitin-activating enzyme E1
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Mus musculus
ubiquitin-activating enzyme E1
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Homo sapiens
ubiquitin-like modifier-activating enzyme 6
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Homo sapiens

General Information

General Information Comment Organism
physiological function isoform Uba6 forms a covalent link with ubiquitin in vitro and in vivo, which is sensitive to reducing conditions. In an in vitro polyubiquitylation assay, recombinant Uba6 can activate ubiquitin and transfer it onto the ubiquitin-conjugating enzyme UbcH5B. Ubiquitin activated by Uba6 can be used for ubiquitylation of p53 by MDM2 and supports the autoubiquitylation of the E3 ubiquitin ligases HectH9 and E6-AP Homo sapiens