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Literature summary for 6.2.1.42 extracted from

  • Wilbrink, M.H.; Petrusma, M.; Dijkhuizen, L.; van der Geize, R.
    FadD19 of Rhodococcus rhodochrous DSM43269, a steroid-coenzyme A ligase essential for degradation of C-24 branched sterol side chains (2011), Appl. Environ. Microbiol., 77, 4455-4464.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Rhodococcus rhodochrous

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 3-oxocholest-4-en-26-oate + CoA Rhodococcus rhodochrous
-
AMP + diphosphate + 3-oxocholest-4-en-26-oyl-CoA
-
?
ATP + 3-oxocholest-4-en-26-oate + CoA Rhodococcus rhodochrous DSM 43269
-
AMP + diphosphate + 3-oxocholest-4-en-26-oyl-CoA
-
?

Organism

Organism UniProt Comment Textmining
Rhodococcus rhodochrous
-
-
-
Rhodococcus rhodochrous DSM 43269
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-oxocholest-4-en-26-oate + CoA
-
Rhodococcus rhodochrous AMP + diphosphate + 3-oxocholest-4-en-26-oyl-CoA
-
?
ATP + 3-oxocholest-4-en-26-oate + CoA
-
Rhodococcus rhodochrous DSM 43269 AMP + diphosphate + 3-oxocholest-4-en-26-oyl-CoA
-
?
ATP + 5-cholenic acid-3beta-ol
-
Rhodococcus rhodochrous ?
-
?
ATP + 5-cholenic acid-3beta-ol
-
Rhodococcus rhodochrous DSM 43269 ?
-
?
ATP + 5-cholestene-26-oic acid-3beta-ol
-
Rhodococcus rhodochrous ?
-
?
ATP + 5-cholestene-26-oic acid-3beta-ol
-
Rhodococcus rhodochrous DSM 43269 ?
-
?

Synonyms

Synonyms Comment Organism
fadD19
-
Rhodococcus rhodochrous

General Information

General Information Comment Organism
malfunction deletion of fadD19 completely blocks side chain degradation of C-24 branched sterols but not that of cholesterol Rhodococcus rhodochrous
metabolism the enzyme essential for degradation of C-24 branched sterol side chains Rhodococcus rhodochrous