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Literature summary for 6.2.1.2 extracted from

  • Kasuya, F.; Igarashi, K.; Fukui, M.; Nokihara, K.
    Purification and characterization of a medium chain acyl-coenzyme A synthetase (1996), Drug Metab. Dispos., 24, 879-883.
    View publication on PubMed
Search for more literature for 6.2.1.2

Activating Compound

Activating Compound Comment Organism Structure
bovine serum albumin
-
 Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide
-
 Bos taurus
salicylic acid
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a medium chain fatty acid or an aromatic acid or an arylacetic acid + CoA Bos taurus the enzyme catalyzes the first reaction of glycine conjugation, which is an important route of detoxification of many xenobiotic and endogenous carboxylic acids ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.718
-
-
 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a medium chain fatty acid or an aromatic acid or an arylacetic acid + CoA the enzyme catalyzes the first reaction of glycine conjugation, which is an important route of detoxification of many xenobiotic and endogenous carboxylic acids Bos taurus ?
-
 ?
ATP + benzoic acid + CoA also active with several benzoic acids substituted at position 2, 3 or 4 Bos taurus AMP + diphosphate + benzoyl-CoA
-
 ?
ATP + dodecanoate + CoA
-
 Bos taurus AMP + diphosphate + dodecanoyl-CoA
-
 ?
ATP + heptanoate + CoA
-
 Bos taurus AMP + diphosphate + heptanoyl-CoA
-
 ?
ATP + hexanoate + CoA highest activity Bos taurus AMP + diphosphate + hexanoyl-CoA
-
 ?
ATP + octanoate + CoA
-
 Bos taurus AMP + diphosphate + octanoyl-CoA
-
 ?

pH Range

pH Minimum pH Maximum Comment Organism
8.5 10 8.5: 53% of maximal activity, 10.0: 80% of maximal activity, a pH-optimum is not observed Bos taurus