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Literature summary for 6.2.1.16 extracted from

  • Aguilo, F.; Camarero, N.; Relat, J.; Marrero, P.F.; Haro, D.
    Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma (2010), Biochem. J., 427, 255-264.
    View publication on PubMed
Search for more literature for 6.2.1.16

Cloned(Commentary)

Cloned (Comment) Organism
AACS DNa and amino acid sequence determination and analysis, and promoter identification and cloning, the human AACS promoter is a peroxisome-proliferator-activated receptor gamm, PPARgamma, target gene, the nuclear receptor is recruited to the AACS promoter by direct interaction with stimulating protein-1, Sp-1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Homo sapiens
-
adipose tissue expression is particularly abundant in white adipose tissue Homo sapiens
-
white adipose tissue AACS gene expression is particularly abundant in white adipose tissue, as it is induced during adipocyte differentiation Homo sapiens
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Synonyms

Synonyms Comment Organism
AACS
-
 Homo sapiens
Acetoacetyl-CoA synthetase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the human AACS promoter is a PPARgamma target gene. Nuclear receptor PPARgamma is recruited to the AACS promoter by direct interaction with Sp1 additional information
Homo sapiens peroxisome-proliferator-activated receptor gamm, PPARgamma, induces AACS and adipogenesis. A PPAR-responsive element, PPRE-independent mechanism might be involved in PPARgamma-mediated AACS gene expression. PPARgamma-dependent activation of the human AACS gene is mediated by the GC boxes up

General Information

General Information Comment Organism
physiological function acetoacetyl-CoA synthetase activates ketone bodies and incorporates them into cholesterol and fatty acids in the cytosol of lipogenic tissue Homo sapiens