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Literature summary for 6.2.1.15 extracted from

  • Reddy, T.S.; Bazan, N.G.
    Kinetic properties of arachidonoyl-coenzyme A synthetase in rat brain microsomes (1983), Arch. Biochem. Biophys., 226, 125-133.
    View publication on PubMed
Search for more literature for 6.2.1.15

Inhibitors

Inhibitors Comment Organism Structure
arachidonate unlabeled arachidonate inhibits arachidonate activation Rattus norvegicus
docosahexaenoate unlabeled Rattus norvegicus
oleate
-
 Rattus norvegicus
palmitate
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008
-
 CoA
-
 Rattus norvegicus
0.036
-
 arachidonate
-
 Rattus norvegicus
0.154
-
 ATP
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ MgCl2 enhances activity Rattus norvegicus
Mg2+ Km: 0.182 mM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain microvessels Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + arachidonate + CoA
-
 Rattus norvegicus AMP + diphosphate + arachidonoyl-CoA
-
 ?
ATP + docosahexaenoate + CoA
-
 Rattus norvegicus ATP + diphosphate + docosahexaenoyl-CoA
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
-
 Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
 half-life: 0.9 min Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
7 9.5 7: about 50% of maximal activity, 9.5: about 70% of maximal activity Rattus norvegicus