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Literature summary for 6.2.1.1 extracted from

  • Thorgersen, M.P.; Lipscomb, G.L.; Schut, G.J.; Kelly, R.M.; Adams, M.W.
    Deletion of acetyl-CoA synthetases I and II increases production of 3-hydroxypropionate by the metabolically-engineered hyperthermophile Pyrococcus furiosus (2014), Metab. Eng., 22C, 83-88.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Pyrococcus furiosus
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-
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Subunits

Subunits Comment Organism
heterotetramer alpha2beta2 Pyrococcus furiosus

Synonyms

Synonyms Comment Organism
Acetyl-CoA synthetase
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Pyrococcus furiosus

General Information

General Information Comment Organism
malfunction deletion of individual and multiple subunits of acetyl-CoA synthetase decreases CoA release activity for several different CoA ester substrates. Deletion of acetyl-CoA synthetases I and II increases production of 3-hydroxypropionate by the metabolically-engineered hyperthermophile Pyrococcus furiosus (containing three enzymes from the CO2 fixation cycle of the thermoacidophilic archaeon Metallosphaerasedula) Pyrococcus furiosus