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Literature summary for 6.2.1.1 extracted from

  • Luong, A.; Hannah, V.C.; Brown, M.S.; Goldstein, J.L.
    Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins (2000), J. Biol. Chem., 275, 26458-26466.
    View publication on PubMed
Search for more literature for 6.2.1.1

Cloned(Commentary)

Cloned (Comment) Organism
production in HEK -293 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
 CoA
-
 Homo sapiens
0.073
-
 acetate
-
 Homo sapiens
0.245
-
 ATP
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78000
-
 1 * 78000, SDS-PAGE Homo sapiens
80000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetate + CoA Homo sapiens the enzyme activates acetate so that it can be used for lipid synthesis or for energy generation. The acetyl-CoA synthetase mRNA, and hence the ability of cells to activate acetate, is regulated by sterol regulatory element-binding proteins in parallel with fatty acid synthesis in animal cells AMP + diphosphate + acetyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NR19
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetate + CoA
-
 Homo sapiens AMP + diphosphate + acetyl-CoA
-
 ?
ATP + acetate + CoA the enzyme activates acetate so that it can be used for lipid synthesis or for energy generation. The acetyl-CoA synthetase mRNA, and hence the ability of cells to activate acetate, is regulated by sterol regulatory element-binding proteins in parallel with fatty acid synthesis in animal cells Homo sapiens AMP + diphosphate + acetyl-CoA
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 78000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ACS
-
 Homo sapiens