Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium leprae | - |
bacilli derived from Armadillo liver | - |
Synonyms | Comment | Organism |
---|---|---|
lysyl tRNA synthetase | - |
Mycobacterium leprae |
Lysyl-tRNA synthetase | - |
Mycobacterium leprae |
General Information | Comment | Organism |
---|---|---|
additional information | similarity between the predicted B cell epitopes of 20 kDa microtubule-stabilizing protein of Bos taurus, MBP (MBP98-104), and 50S ribosomal protein L2 or lysyl-tRNA synthetase of Mycobacterium leprae. Two B cell epitopes of MBP98-104 with 50S ribosomal protein L2226-237 and MBP127-131 and MBP55-60 with 50S ribosomal protein L2 of Mycobacterium leprae41-46 are mimicking epitopes. While, 2 B cell epitopes of MBP85-98 with lysyl tRNA synthetase388-401 and MBP99-104 with lysyl tRNA synthetase472-477 are mimicking with each other | Mycobacterium leprae |
physiological function | four B cell epitopes of myelin A1 and Mycobacterium leprae proteins, 50S ribosomal L2 and lysyl tRNA synthetase are cross-reactive. Further, Mycobacterium leprae sonicated antigen hyperimmunization is responsible for induction of autoantibody response in mice. Role of molecular mimicry in nerve damage in leprosy | Mycobacterium leprae |