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Literature summary for 6.1.1.6 extracted from

  • Oka, M.; Takegawa, K.; Kimura, Y.
    Lysyl-tRNA synthetase from Myxococcus xanthus catalyzes the formation of diadenosine penta- and hexaphosphates from adenosine tetraphosphate (2016), Arch. Biochem. Biophys., 604, 152-158 .
    View publication on PubMed
Search for more literature for 6.1.1.6

Inhibitors

Inhibitors Comment Organism Structure
additional information the formation of diadenosine tetraphosphate (Ap4A) by LysS is inhibited by tRNA(Lys) in the presence of 1 mM ATP Myxococcus xanthus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Myxococcus xanthus lysyl-tRNA synthetase from Myxococcus xanthus catalyzes the formation of diadenosine penta- and hexaphosphates from adenosine tetraphosphate ?
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additional information Myxococcus xanthus DK 1622 lysyl-tRNA synthetase from Myxococcus xanthus catalyzes the formation of diadenosine penta- and hexaphosphates from adenosine tetraphosphate ?
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Organism

Organism UniProt Comment Textmining
Myxococcus xanthus Q1D380
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Myxococcus xanthus DK 1622 Q1D380
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information lysyl-tRNA synthetase from Myxococcus xanthus catalyzes the formation of diadenosine penta- and hexaphosphates from adenosine tetraphosphate Myxococcus xanthus ?
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 ?
additional information enzyme LysS produces diadenosine tetraphosphate (Ap4A) from ATP in the presence of Mn2+, it also generates Ap4 from ATP and triphosphate. When ATP and Ap4 are incubated with LysS and diphosphatase, first Ap4A, Ap5A, and ADP, and then Ap5, Ap6A, and Ap3A are generated. In the first reaction step, LysS can form lysyl-AMP and lysyl-ADP intermediates from Ap4 and release triphosphate and diphosphate, respectively, whereas in the second step, it can produce Ap5 from lysyl-ADP with triphosphate, and Ap6A from lysyl-ADP with Ap4. In addition, in the presence of Ap4 and diphosphatase, but absence of ATP, LysS also generates diadenosine oligophosphates (ApnAs: n = 3-6). The formation of diadenosine tetraphosphate (Ap4A) by LysS is inhibited by tRNA(Lys) in the presence of 1 mM ATP Myxococcus xanthus ?
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 ?
additional information lysyl-tRNA synthetase from Myxococcus xanthus catalyzes the formation of diadenosine penta- and hexaphosphates from adenosine tetraphosphate Myxococcus xanthus DK 1622 ?
-
 ?
additional information enzyme LysS produces diadenosine tetraphosphate (Ap4A) from ATP in the presence of Mn2+, it also generates Ap4 from ATP and triphosphate. When ATP and Ap4 are incubated with LysS and diphosphatase, first Ap4A, Ap5A, and ADP, and then Ap5, Ap6A, and Ap3A are generated. In the first reaction step, LysS can form lysyl-AMP and lysyl-ADP intermediates from Ap4 and release triphosphate and diphosphate, respectively, whereas in the second step, it can produce Ap5 from lysyl-ADP with triphosphate, and Ap6A from lysyl-ADP with Ap4. In addition, in the presence of Ap4 and diphosphatase, but absence of ATP, LysS also generates diadenosine oligophosphates (ApnAs: n = 3-6). The formation of diadenosine tetraphosphate (Ap4A) by LysS is inhibited by tRNA(Lys) in the presence of 1 mM ATP Myxococcus xanthus DK 1622 ?
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 ?

Synonyms

Synonyms Comment Organism
lysS
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 Myxococcus xanthus
Lysyl-tRNA synthetase
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 Myxococcus xanthus