Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-lysine + tRNALys | pathology-related human mitochondrial tRNA(Lys) variants as substrates. G8313A or G8328A mutations in tRNA(Lys) lead to drastic decreases (500fold to 7000fold) in lysylation efficiency. Mutations in tRNA(Lys) that have no effect on aminoacylation: A8296G, U8316G, G8342A, U8356C, U8362G, G8363A | Homo sapiens | AMP + L-lysyl-tRNALys + diphosphate | - |
? |