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Literature summary for 6.1.1.6 extracted from

  • Halwani, R.; Cen, S.; Javanbakht, H.; Saadatmand, J.; Kim, S.; Shiba, K.; Kleiman, L.
    Cellular distribution of Lysyl-tRNA synthetase and its interaction with Gag during human immunodeficiency virus type 1 assembly (2004), J. Virol., 78, 7553-7564.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.6

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm of HIV-1-producing 293FT cells Homo sapiens 5737
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mitochondrion of HIV-1-producing 293FT cells Homo sapiens 5739
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nucleus of HIV-1-producing 293FT cells Homo sapiens 5634
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plasma membrane associated with plasma membrane of HIV-1-producing 293FT cells Homo sapiens 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-lysine + tRNALys Homo sapiens enzyme facilitates the selective packaging of tRNA3 Lys. Newly synthesized LysRS is associated with Gag protein after a 10 minute pulse with [35 S]cysteine/methionine. Incorporation of LysRS into HIV-1 is very sensitive to the inhibition of new synthesis of LysRS AMP + L-lysyl-tRNALys + diphosphate
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
293FT cell HIV-1 producing Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-lysine + tRNALys
-
 Homo sapiens AMP + L-lysyl-tRNALys + diphosphate
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 ?
ATP + L-lysine + tRNALys enzyme facilitates the selective packaging of tRNA3 Lys. Newly synthesized LysRS is associated with Gag protein after a 10 minute pulse with [35 S]cysteine/methionine. Incorporation of LysRS into HIV-1 is very sensitive to the inhibition of new synthesis of LysRS Homo sapiens AMP + L-lysyl-tRNALys + diphosphate
-
 ?