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Literature summary for 6.1.1.6 extracted from

  • Plateau, P.; Blanquet, S.
    Zinc-dependent synthesis of various dinucleoside 5', 5'''-P1, P3-tri or 5', 5'''-P1,P4-tetraphosphates by Escherichia coli lysyl-tRNA synthetase (1982), Biochemistry, 21, 5273-5279.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ 0.06 mM, 50% inhibition of aminoacylation, stimulation of synthesis of mixed dinucleoside 5',5'''-P1,P4-tri- or 5',5''''-P1,P4-tetraphosphates resulting from the reaction of lysyl adenylate with a variety of ribo- (or deoxyribo-)nucleotides 5'-tri-(or 5'-di-)phosphates Escherichia coli
Zn2+ stimulation of diadenosine 5',5'''-P1,P4-tetraphosphate synthetase activity Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + lysine + tRNALys
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Escherichia coli AMP + L-lysyl-tRNALys + diphosphate
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additional information synthesis of mixed dinucleoside 5',5'''-P1,P4-triphosphates or 5',5''''-P1,P4-tetraphosphates resulting from the reaction of lysyl adenylate with a variety of ribonucleotide 5'-triphosphates, ribonucleotide 5'-diphosphates, deoxyribonucleotide 5'-diphosphates or deoxyribonucleotide 5'-triphosphates Escherichia coli ?
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additional information L-lysine-dependent synthesis of 5',5'-diadenosine tetraphosphate (Ap4A) Escherichia coli ?
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