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Literature summary for 6.1.1.5 extracted from
- Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases (2001), Bioorg. Med. Chem. Lett., 11, 961-964.
Application
| Application | Comment | Organism |
|---|---|---|
| molecular biology | enzyme is a target for receptor-guided inhibitor design | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ester analogues of isoleucyl adenylate | with or without cyclic substitutents at the adenine moiety | Escherichia coli |  |
| hydroxamate analogues of isoleucyl adenylate | with or without cyclic substitutents at the adenine moiety | Escherichia coli | |
| additional information | inhibition mechanism and structural determinants | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-isoleucine + tRNAIle | Escherichia coli | - |
AMP + diphosphate + L-isoleucyl-tRNAIle | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-isoleucine + tRNAIle | - |
Escherichia coli | AMP + diphosphate + L-isoleucyl-tRNAIle | - |
? | |
| ATP + L-isoleucine + tRNAIle | the binding region of the adenine moiety contains a wide hydrophobic pocket large enough to afford three linear aromatic rings | Escherichia coli | AMP + diphosphate + L-isoleucyl-tRNAIle | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IleRS | - |
Escherichia coli |
| IRS | - |
Escherichia coli |
| Isoleucine translase | - |
Escherichia coli |
| Isoleucine--tRNA ligase | - |
Escherichia coli |
| Isoleucine-transfer RNA ligase | - |
Escherichia coli |
| Isoleucine-tRNA synthetase | - |
Escherichia coli |
| Isoleucyl-transfer ribonucleate synthetase | - |
Escherichia coli |
| Isoleucyl-transfer RNA synthetase | - |
Escherichia coli |
| Isoleucyl-tRNA synthetase | - |
Escherichia coli |
| Mupirocin resistance protein | - |
Escherichia coli |
| Synthetase, isoleucyl-transfer ribonucleate | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Escherichia coli | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Escherichia coli |
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