Literature summary for 6.1.1.5 extracted from

Freist, W.; von der Haar, F.; Cramer, F.
Isoleucyl-tRNA synthetase from baker's yeast (1981), Eur. J. Biochem., 119, 151-164.

Search for more literature for 6.1.1.5

Inhibitors

Inhibitors	Comment	Organism	Structure
3'-deoxyadenosine	i.e. cordycepin	Saccharomyces cerevisiae
8-Aminoadenosine	-	Saccharomyces cerevisiae
8-azidoadenosine 5'-triphosphate	-	Saccharomyces cerevisiae
purineriboside	i.e. nebularin	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle	mechanism of aminoacylation in absence of diphosphatase is ordered ter-ter, in presence of diphosphatase random bi-uni uni-bi ping-pong	Saccharomyces cerevisiae	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-isoleucine + tRNAIle	-	Saccharomyces cerevisiae	AMP + diphosphate + L-isoleucyl-tRNAIle	-	?
additional information	Ile + ATP + enzyme/Ile-AMP-enzyme + diphosphate, isoleucine-dependent ATP-diphosphate exchange	Saccharomyces cerevisiae	?	-	?

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Release 2023.1 (January 2023)