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Literature summary for 6.1.1.4 extracted from

  • Li, L.; Palencia, A.; Lukk, T.; Li, Z.; Luthey-Schulten, Z.A.; Cusack, S.; Martinis, S.A.; Boniecki, M.T.
    Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens (2013), Proc. Natl. Acad. Sci. USA, 110, 3817-3822.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.4

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, using 0.1 M bis-Tris (pH 5.5), 0.6 M ammonium acetate, and 20% (w/v) PEG3350 at 4°C Mesomycoplasma mobile

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains zinc Mycoplasmopsis synoviae
Zn2+ contains zinc Mesomycoplasma mobile

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-leucine + tRNALeu Mycoplasmopsis synoviae
-
 AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
ATP + L-leucine + tRNALeu Mesomycoplasma mobile
-
 AMP + diphosphate + L-leucyl-tRNALeu
-
 ?

Organism

Organism UniProt Comment Textmining
Mesomycoplasma mobile
-
-
-
Mycoplasmopsis synoviae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-isoleucine + 2'-deoxaadenosine-tRNALeu 2'-deoxyadenosine-tRNA clearly stimulates AMP production in the presence of isoleucine, but not the cognate leucine substrate Mycoplasmopsis synoviae AMP + ?
-
 ?
ATP + L-leucine + tRNALeu
-
 Mycoplasmopsis synoviae AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
ATP + L-leucine + tRNALeu
-
 Mesomycoplasma mobile AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
additional information the enzyme maintains weak pre-transfer editing activities Mycoplasmopsis synoviae ?
-
 ?
additional information the enzyme maintains weak pretransfer editing activities Mesomycoplasma mobile ?
-
 ?

Synonyms

Synonyms Comment Organism
Leucyl-tRNA synthetase
-
 Mycoplasmopsis synoviae
Leucyl-tRNA synthetase
-
 Mesomycoplasma mobile
LeuRS
-
 Mycoplasmopsis synoviae
LeuRS
-
 Mesomycoplasma mobile

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mycoplasmopsis synoviae
ATP
-
 Mesomycoplasma mobile

General Information

General Information Comment Organism
physiological function the enzyme naturally produces mischarged tRNALeu Mycoplasmopsis synoviae
physiological function the enzyme naturally produces mischarged tRNALeu Mesomycoplasma mobile