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Literature summary for 6.1.1.4 extracted from
- A glycine hinge for tRNA-dependent translocation of editing substrates to prevent errors by leucyl-tRNA synthetase (2009), FEBS Lett., 583, 3443-3447.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G225P | abolishes tRNA leucylation due to a defect in leucine activation, decrease in deacylation of Ile-tRNALeu | Escherichia coli |
| G229P | increased aminoacylation activity compared to the wild-type, mutant deacylates Ile-tRNALeu similar to wild-type | Escherichia coli |
| G229P/T252A | double mutant rescues leucylation activity to levels comparable to wild-type and retains deacylation activity of LeutRNALeu that is characteristic of the T252A mutation | Escherichia coli |
| G407P | aminoacylates tRNALeu and decylates Ile-tRNALeu as well as wild-type | Escherichia coli |
| G409P | increased aminoacylation activity compared to the wild-type, mutant deacylates Ile-tRNALeu similar to wild-type | Escherichia coli |
| G409P/T252A | double mutant fails to rescue the T252A mutation in LeuRS | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
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Release 2023.1 (January 2023)
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