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Literature summary for 6.1.1.4 extracted from

  • Zhu, B.; Zhao, M.W.; Eriani, G.; Wang, E.D.
    A present-day aminoacyl-tRNA synthetase with ancestral editing properties (2007), RNA, 13, 15-21.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information the freestanding LeuRS editing domain can edit this precursor in contrast to IleRS and ValRS editing domains, overview, design and preparation of minihelixLIV, overview Aquifex aeolicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics of mischarging and post-transfer editing activities, overview Aquifex aeolicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Aquifex aeolicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-leucine + tRNALeu Aquifex aeolicus
-
AMP + diphosphate + L-leucyl-tRNALeu
-
?

Organism

Organism UniProt Comment Textmining
Aquifex aeolicus
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
mischarging and post-transfer editing activities, overview Aquifex aeolicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-leucine + tRNALeu
-
Aquifex aeolicus AMP + diphosphate + L-leucyl-tRNALeu
-
?
ATP + L-leucine + tRNALeu the enzyme hydrolyzes mischarged tRNAs through a post-transfer editing mechanism, the enzyme from Aquifex aeolicus edits the complete set of aminoacylated tRNAs generated by the three enzymes, leucyl-, isoleucyl-, and valyl-tRNA synthetases: Ile-tRNAIle, Val-tRNAIle, ValtRNAVal, Thr-tRNAVal, and Ile-tRNALeu, model of a primitive editing system containing a composite minihelix carrying the triple leucine, isoleucine, and valine identity mimicking the primitive tRNA precursor, overview Aquifex aeolicus AMP + diphosphate + L-leucyl-tRNALeu
-
?

Synonyms

Synonyms Comment Organism
Leucyl-tRNA synthetase
-
Aquifex aeolicus
LeuRS
-
Aquifex aeolicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at with the minihelix Aquifex aeolicus
37
-
assay at Aquifex aeolicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Aquifex aeolicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Aquifex aeolicus