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Literature summary for 6.1.1.22 extracted from
- Computational protein design with a generalized born solvent model: application to asparaginyl-tRNA synthetase (2011), Proteins, 79, 3448-3468.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thermus thermophilus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AsnRS | - |
Thermus thermophilus |
| Asparaginyl-tRNA synthetase | - |
Thermus thermophilus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Thermus thermophilus | engineering of aspartyladenylate, AspAMP, specificity into asparaginyl-tRNA synthetase, AsnRS, whose substrate is asparaginyl-adenylate by CPD method, that uses a polar-hydrogen energy function for protein interactions and a coulomb/accessible surface area model for solvent effects, method development, overview. Application of an all-atom energy for protein interactions and a residue-pairwise generalized Born model for solvent effects, overview. The conformations and interactions are well maintained in molecular dynamics simulations and the sequences have an inverted specificity, favoring AspAMP over AsnAMP | additional information |
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Release 2023.1 (January 2023)
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