Literature summary for 6.1.1.2 extracted from

Kise, Y.; Lee, S.W.; Park, S.G.; Fukai, S.; Sengoku, T.; Ishii, R.; Yokoyama, S.; Kim, S.; Nureki, O.
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase (2004), Nat. Struct. Mol. Biol., 11, 149-156.

Search for more literature for 6.1.1.2

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of miniTrpRS in Escherichia coli BL21	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystals of native mini TrpRS are obtained by hanging-drop vapor diffusion at 4°C, crystal structure of human mini TrpRS is determined at a resolution of 2.3 A	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D382-TIEEHR-Q389	deletion of the tRNA anticodon-binding domain insertion, consisting of eight residues in the human TrpRS, abolishes the apoptotic activity of the enzyme for endothelial cells, whereas its translational catalysis and cell-binding activities remain unchanged	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	enzyme is secreted into the extracellular region of vascular endothelial cells	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P23381	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
vascular endothelial cell	-	Homo sapiens	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)