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Literature summary for 6.1.1.2 extracted from

  • Yang, X.L.; Otero, F.J.; Skene, R.J.; McRee, D.E.; Schimmel, P.; de Pouplana, L.R.
    Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains (2003), Proc. Natl. Acad. Sci. USA, 100, 15376-15380.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.2

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure determination at 2.1 A resolution of the enzyme with a tryptophanyladenylate bound at the active site, cocrystal structure determination at 1.6 A resolution of an active fragment of the enzyme with its cognate amino acid analogue Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-tryptophan + tRNATrp Homo sapiens
-
 AMP + diphosphate + L-tryptophan-tRNATrp
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P23381
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + L-tryptophan + tRNATrp = AMP + diphosphate + L-tryptophyl-tRNATrp active site, 2 critical positions for amino acid discrimination Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-tryptophan + tRNATrp
-
 Homo sapiens AMP + diphosphate + L-tryptophan-tRNATrp
-
 ?

Synonyms

Synonyms Comment Organism
Tryptophanyl-tRNA synthase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens