Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interferon gamma | strong upregulation of the alternatively spliced truncated mini enzyme form | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tryptophan + tRNATrp | Homo sapiens | enzyme contributes to biological processes involving cell signaling such as angiogenesis regulation | AMP + diphosphate + L-tryptophan-tRNATrp | - |
? | |
additional information | Homo sapiens | the enzymes C-terminal domain, an EMAP II-like protein, inhibits angiogenesis signaling pathways and the development of blood vessels | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | regulated mechanism, the C-terminal domain of the enzyme, which has anti-angiogenic activity and inhibits immune cells, is isolated by proteolytic cleavage or alternative splicing, the mini enzyme is a potent inhibitor of blood vessel development, the full-length enzyme is inactive, enzyme N-terminally processed by elastase, resulting in 2 different forms T1 and T2, has also anti-angiogenic activity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
endothelium | umbilical vein | Homo sapiens | - |
lung | - |
Homo sapiens | - |
additional information | tissue-specific gen expression | Homo sapiens | - |
placenta | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
trachea | - |
Homo sapiens | - |
umbilical vein | endothelial cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tryptophan + tRNATrp | - |
Homo sapiens | AMP + diphosphate + L-tryptophan-tRNATrp | - |
? | |
ATP + L-tryptophan + tRNATrp | enzyme contributes to biological processes involving cell signaling such as angiogenesis regulation | Homo sapiens | AMP + diphosphate + L-tryptophan-tRNATrp | - |
? | |
additional information | the enzymes C-terminal domain, an EMAP II-like protein, inhibits angiogenesis signaling pathways and the development of blood vessels | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TrpRS | - |
Homo sapiens |
Tryptophanyl-tRNA synthase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |