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Literature summary for 6.1.1.15 extracted from

  • Sampath, P.; Mazumder, B.; Seshadri, V.; Gerber, C.A.; Chavatte, L.; Kinter, M.; Ting, S.M.; Dignam, J.D.; Kim, S.; Driscoll, D.M.; Fox, P.L.
    Noncanonical function of glutamyl-prolyl-tRNA synthetase: Gene-specific silencing of translation (2004), Cell, 119, 195-208.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens in addition to enzymic activity, glutamyl-prolyl-tRNA synthetase is phosphorylated in response to interferon-gamma, binds the ceruloplasmin 3'-untranslated region in an mRNP containing three additional proteins, and silences ceruloplasmin mRNA translation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoform glutamyl-prolyl-tRNA synthetase
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein glutamyl-prolyl-tRNA synthetase is phosphorylated in response to interferon-gamma Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
U-937 cell monocytic cell culture Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information in addition to enzymic activity, glutamyl-prolyl-tRNA synthetase is phosphorylated in response to interferon-gamma, binds the ceruloplasmin 3'-untranslated region in an mRNP containing three additional proteins, and silences ceruloplasmin mRNA translation Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More glutamyl-prolyl-tRNA synthetase is a component of the interferon gamma-activated inhibitor of translation complex Homo sapiens