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Literature summary for 6.1.1.14 extracted from
- Translational efficiency of a non-AUG initiation codon is significantly affected by its sequence context in yeast (2008), J. Biol. Chem., 283, 3173-3180.
Application
| Application | Comment | Organism |
|---|---|---|
| molecular biology | translation of mRNA for yeast glycyl-tRNA synthetase is alternatively initiated from UUG and a downstream AUG initiation codon. Unlike an AUG initiation codon, efficiency of this non-AUG initiation codon is significantly affected by its sequence context, in particular the nucleotides at positions -3 to -1 relative to the initiation codon. A/A/R (R: A or G) and C/G/C appear to be the most and least favorable sequences at these positions, respectively. Mutation of the native context sequence -3 to -1 from AAA to CGC reduce translation initiation from the UUG codon up to 32fold and resulted in loss of mitochondrial respiration | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycyl-tRNA synthetase 1 | - |
Saccharomyces cerevisiae |
| GRS1 | - |
Saccharomyces cerevisiae |
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