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Literature summary for 6.1.1.12 extracted from

  • Merritt, E.A.; Arakaki, T.L.; Larson, E.T.; Kelley, A.; Mueller, N.; Napuli, A.J.; Zhang, L.; Deditta, G.; Luft, J.; Verlinde, C.L.; Fan, E.; Zucker, F.; Buckner, F.S.; Van Voorhis, W.C.; Hol, W.G.
    Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica (2010), Mol. Biochem. Parasitol., 169, 95-100.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.12

Cloned(Commentary)

Cloned (Comment) Organism
the full length sequence is cloned into the AVA0421 vector Entamoeba histolytica

Crystallization (Commentary)

Crystallization (Comment) Organism
the crystal structure of aspartyl-tRNA synthetase is determined at 2.8 A resolution Entamoeba histolytica

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Entamoeba histolytica 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-aspartate + tRNAAsp Entamoeba histolytica
-
 AMP + diphosphate + L-aspartyl-tRNAAsp
-
 ?

Organism

Organism UniProt Comment Textmining
Entamoeba histolytica C4LZN0
-
-

Purification (Commentary)

Purification (Comment) Organism
on a Ni-NTA affinity column followed by cleavage of the N-terminal affinity tag Entamoeba histolytica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-aspartate + tRNAAsp
-
 Entamoeba histolytica AMP + diphosphate + L-aspartyl-tRNAAsp
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Entamoeba histolytica

Synonyms

Synonyms Comment Organism
Aspartyl-tRNA synthetase
-
 Entamoeba histolytica
AspRS
-
 Entamoeba histolytica

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Entamoeba histolytica