Literature summary for 6.1.1.11 extracted from

Kim, Y.K.; Lee, J.Y.; Cho, H.S.; Lee, S.S.; Ha, H.J.; Kim, S.; Choi, D.; Pai, H.S.
Inactivation of organellar glutamyl- and seryl-tRNA synthetases leads to developmental arrest of chloroplasts and mitochondria in higher plants (2005), J. Biol. Chem., 280, 37098-37106.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-serine + tRNASer	Nicotiana benthamiana	gene silencing of the Nicotiana benthamiana SerRS causes severe leaf yellowing and abnormal leaf morphology, while maintaining almost normal plant growth. At the cell level depletion of the NcSRS gene results in dramatically reduced numbers of chloroplasts with reduced sizes and chlorophyll content. The numbers and/or physiology of mitochondria are also severely affected. The abnormal chloroplasts lack most of the thylakoid membranes and appear to be degenerating, whereas some of them show doublet morphology, indicating defective chloroplast division	AMP + diphosphate + L-seryl-tRNASer	-	?

Organism

Organism	UniProt	Comment	Textmining
Nicotiana benthamiana	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-serine + tRNASer	-	Nicotiana benthamiana	AMP + diphosphate + L-seryl-tRNASer	-	?
ATP + L-serine + tRNASer	gene silencing of the Nicotiana benthamiana SerRS causes severe leaf yellowing and abnormal leaf morphology, while maintaining almost normal plant growth. At the cell level depletion of the NcSRS gene results in dramatically reduced numbers of chloroplasts with reduced sizes and chlorophyll content. The numbers and/or physiology of mitochondria are also severely affected. The abnormal chloroplasts lack most of the thylakoid membranes and appear to be degenerating, whereas some of them show doublet morphology, indicating defective chloroplast division	Nicotiana benthamiana	AMP + diphosphate + L-seryl-tRNASer	-	?

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Release 2023.1 (January 2023)