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Literature summary for 6.1.1.1 extracted from
- Decreased aminoacylation in pathology-related mutants of mitochondrial tRNATyr is associated with structural perturbations in tRNA architecture (2008), RNA, 14, 641-648.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.8 | - |
G15A mutated tRNATyr transcript | - |
Homo sapiens | |
| 1.6 | - |
A22G mutated tRNATyr transcript | - |
Homo sapiens | |
| 2.2 | - |
U54C mutated tRNATyr transcript | - |
Homo sapiens | |
| 4.8 | - |
tRNATyr | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
in vitro tyrosylation efficiency is decreased 600fold for mutant A22G (mitochondrial gene mutation T5874C), 40fold for G15A (C5877T), and is without significant effect on U54C (A5843G) | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-tyrosine + tRNATyr | - |
Homo sapiens | AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? | |
| ATP + L-tyrosine + tRNATyr + A22G mutated tRNATyr transcript | - |
Homo sapiens | ? | - |
? | |
| ATP + L-tyrosine + tRNATyr + G15A mutated tRNATyr transcript | - |
Homo sapiens | ? | - |
? | |
| ATP + L-tyrosine + tRNATyr + U54C mutated tRNATyr transcript | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Tyrosyl-tRNA synthetase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00003 | - |
A22G mutated tRNATyr transcript | - |
Homo sapiens | |
| 0.0002 | - |
G15A mutated tRNATyr transcript | - |
Homo sapiens | |
| 0.012 | - |
U54C mutated tRNATyr transcript | - |
Homo sapiens | |
| 0.046 | - |
tRNATyr | - |
Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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