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Literature summary for 5.5.1.4 extracted from
- E2F1 regulation of the human myo-inositol 1-phosphate synthase (ISYNA1) gene promoter (2004), Arch. Biochem. Biophys., 431, 95-106.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene ISYNA1 is upregulated by E2F1 acting on the minimal promoter, which can be suppressed by retinoblastoma protein, E2F1 functional binding motif determination at -117 overlapping an Sp1 motif, upregulation probably by interaction with several other low-affinity E2F1 binding motifs | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Glucose 6-phosphate | Homo sapiens | - |
L-myo-Inositol 1-phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
gene ISYNA1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Glucose 6-phosphate | - |
Homo sapiens | L-myo-Inositol 1-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IP synthase | - |
Homo sapiens |
| myo-inositol 1-phosphate synthase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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