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Literature summary for 5.5.1.4 extracted from

  • Wong, Y.H.H.; Mauck, L.A.; Sherman, W.R.
    L-myo-Inositol-1-phosphate synthase from bovine testis (1982), Methods Enzymol., 90, 309-314.
    View publication on PubMed
Search for more literature for 5.5.1.4

Activating Compound

Activating Compound Comment Organism Structure
NH4+ stimulates Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
2-Deoxy-2-fluoroglucose 6-phosphate
-
 Bos taurus
2-deoxy-D-glucose 6-phosphate
-
 Bos taurus
Cd2+
-
 Bos taurus
Cu2+
-
 Bos taurus
D-mannose 6-phosphate
-
 Bos taurus
EDTA no inhibition Bos taurus
Na+
-
 Bos taurus
Zn2+
-
 Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
K+ stimulates 2fold and with added K+, 2.5fold Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
209000
-
 equilibrium centrifugation Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-deoxy-D-glucose 6-phosphate at 11.5% of the activity relative to D-glucose 6-phosphate Bos taurus 5-deoxy-L-myo-inositol 1-phosphate
-
 ?
D-2-Deoxy-2-fluoroglucose 6-phosphate at 0.2% of the activity relative to D-glucose 6-phosphate Bos taurus 5-Deoxy-5-fluoro-myo-inositol 1-phosphate
-
 ?
D-Glucose 6-phosphate
-
 Bos taurus L-myo-Inositol 1-phosphate
-
 ?
D-Mannose 6-phosphate at 11.5% of the activity relative to D-glucose 6-phosphate Bos taurus myo-Inositol 1-phosphate
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor, Km: 0.011 mM Bos taurus