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Literature summary for 5.5.1.4 extracted from

  • Barnett, J.E.G.; Rasheed, A.; Corina, D.L.
    Partial reactions of D-glucose 6-phosphate-1L-myoinositol 1-phosphate cyclase (1973), Biochem. J., 131, 21-30.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.5.1.4

Inhibitors

Inhibitors Comment Organism Structure
D-sorbitol 6-phosphate
-
 Rattus norvegicus
NaBH4 partial inactivation in presence of NAD+. No inactivation in absence of NAD+ Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
215000
-
 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate formation of 5-keto-D-glucose 6-phosphate as an enzyme-bound intermediate in the conversion of D-glucose 6-phosphate into 1L-myo-inositol 1-phosphate Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Glucose 6-phosphate
-
 Rattus norvegicus L-myo-Inositol 1-phosphate
-
 ?
additional information after removal of tightly bound NAD+ the enzyme catalyzes the reduction of 5-keto-D-glucitol 6-phosphate and 5-keto-D-glucose 6-phosphate by NADH to give glucitol 6-phosphate and glucose 6-phosphate respectively Rattus norvegicus ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+ tightly bound Rattus norvegicus
NAD+ Km: 0.05 mM Rattus norvegicus