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Literature summary for 5.5.1.11 extracted from

  • Pieper, D.H.; Stadler-Fritzsche, K.; Engesser, K.H.; Knackmuss, H.J.
    Metabolism of 2-chloro-4-methylphenoxyacetate by Alcaligenes eutrophus JMP 134 (1993), Arch. Microbiol., 160, 169-178.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.06
-
2-chloro-4-methyl-cis,cis-muconate pH 8.0 Cupriavidus necator

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,4-dichloro-cis,cis-muconate Cupriavidus necator enzyme is involved in 3,5-dichloro-catechol metabolism 4-carboxymethylene-3-chlorobut-2-en-4-olide + HCl The intermediate (2,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetic acid (i.e. 3,5-dichloro-2,5-dihydro-2-oxofuran-5-acetate) is spontanously dehalogenated to 4-carboxymethylene-3-chlorobut-2-en-4-olide (i.e. 2-chlorodienelactone) ir

Organism

Organism UniProt Comment Textmining
Cupriavidus necator
-
JMP 134
-
Cupriavidus necator JMP 134-1
-
JMP 134
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.13
-
enzyme from cells induced with 2-chloro-4-methylphenoxyacetic acid Cupriavidus necator
0.24
-
enzyme from cells induced with 2,4-dichlorophenoxyacetic acid Cupriavidus necator

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-dichloro-cis,cis-muconate
-
Cupriavidus necator 4-carboxymethylene-3-chlorobut-2-en-4-olide + HCl The intermediate (2,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetic acid (i.e. 3,5-dichloro-2,5-dihydro-2-oxofuran-5-acetate) is spontanously dehalogenated to 4-carboxymethylene-3-chlorobut-2-en-4-olide (i.e. 2-chlorodienelactone) ir
2,4-dichloro-cis,cis-muconate enzyme is involved in 3,5-dichloro-catechol metabolism Cupriavidus necator 4-carboxymethylene-3-chlorobut-2-en-4-olide + HCl The intermediate (2,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetic acid (i.e. 3,5-dichloro-2,5-dihydro-2-oxofuran-5-acetate) is spontanously dehalogenated to 4-carboxymethylene-3-chlorobut-2-en-4-olide (i.e. 2-chlorodienelactone) ir
2,4-dichloro-cis,cis-muconate
-
Cupriavidus necator JMP 134-1 4-carboxymethylene-3-chlorobut-2-en-4-olide + HCl The intermediate (2,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetic acid (i.e. 3,5-dichloro-2,5-dihydro-2-oxofuran-5-acetate) is spontanously dehalogenated to 4-carboxymethylene-3-chlorobut-2-en-4-olide (i.e. 2-chlorodienelactone) ir
2-chloro-4-methyl-cis,cis-muconate
-
Cupriavidus necator 2-chloro-4-methyl-muconolactone 4-carboxymethyl-2-chlorobut-4-methylbut-2-en-4-olide ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information kcat of 2-chloro-4-methyl-cis,cis-musconate is about 55% of that found for 2,4-dichloro-cis,cis-musconate Cupriavidus necator