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Literature summary for 5.5.1.1 extracted from

  • Babbitt, P.C.; Mrachko, G.T.; Hasson, M.S.; Huisman, G.W.; Kolter, R.; Ringe, D.; Petsko, G.A.; Kenyon, G.L.; Gerlt, J.A.
    A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids (1995), Science, 267, 1159-1161.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Pseudomonas putida

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cis,cis-Muconate Pseudomonas putida enzyme of the benzoate catabolism ?
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas putida
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(+)-muconolactone = cis,cis-muconate in the reverse reaction the alpha proton of muconolactone is abstracted by a homolog of Lys166(Lys169) to generate an enolic intermediate, this intermediate undergoes vinylopous beta-elimination of the remote carboxylate group to produce cis,cis-muconate Pseudomonas putida

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cis,cis-Muconate i.e. cis,cis-2,4-hexadiendioate, , r Pseudomonas putida (+)-Muconolactone
-
?
cis,cis-Muconate enzyme of the benzoate catabolism Pseudomonas putida ?
-
?