Literature summary for 5.4.99.B22 extracted from

Fitzek, E.; Joardar, A.; Gupta, R.; Geisler, M.
Evolution of eukaryal and archaeal pseudouridine synthase Pus10 (2018), J. Mol. Evol., 86, 77-89 .

Search for more literature for 5.4.99.B22

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	F4HSS8	-	-
Homo sapiens	Q3MIT2	-	-
Methanocaldococcus jannaschii	Q60346	-	-
Pyrococcus furiosus	Q8U1R6	-	-

Synonyms

Synonyms	Comment	Organism
pseudouridine synthase Pus10	-	Homo sapiens
pseudouridine synthase Pus10	-	Methanocaldococcus jannaschii
pseudouridine synthase Pus10	-	Arabidopsis thaliana
pseudouridine synthase Pus10	-	Pyrococcus furiosus

General Information

General Information	Comment	Organism
evolution	eukaryal Pus10 genes share a conserved catalytic domain with archaeal Pus10 genes. Pus10 is found in earlier evolutionary branches of fungi (such as chytrid Batrachochytrium) but is absent in all dikaryon fungi surveyed (Ascomycetes and Basidiomycetes). Orthologs of Pus10, TrmA, and TruB are present in all the animals, plants, and protozoa surveyed. This indicates that the common eukaryotic ancestor possesses all the three genes. Pus10 exists as a single copy gene in all the surveyed genomes despite ancestral whole genome duplications has occurred. This indicates a possible deleterious gene dosage effect. Functional redundancy results in gene loss or neofunctionalization in different evolutionary lineages	Homo sapiens
evolution	eukaryal Pus10 genes share a conserved catalytic domain with archaeal Pus10 genes. Pus10 is found in earlier evolutionary branches of fungi (such as chytrid Batrachochytrium) but is absent in all dikaryon fungi surveyed (Ascomycetes and Basidiomycetes). Orthologs of Pus10, TrmA, and TruB are present in all the animals, plants, and protozoa surveyed. This indicates that the common eukaryotic ancestor possesses all the three genes. Pus10 exists as a single copy gene in all the surveyed genomes despite ancestral whole genome duplications has occurred. This indicates a possible deleterious gene dosage effect. Functional redundancy results in gene loss or neofunctionalization in different evolutionary lineages	Methanocaldococcus jannaschii
evolution	eukaryal Pus10 genes share a conserved catalytic domain with archaeal Pus10 genes. Pus10 is found in earlier evolutionary branches of fungi (such as chytrid Batrachochytrium) but is absent in all dikaryon fungi surveyed (Ascomycetes and Basidiomycetes). Orthologs of Pus10, TrmA, and TruB are present in all the animals, plants, and protozoa surveyed. This indicates that the common eukaryotic ancestor possesses all the three genes. Pus10 exists as a single copy gene in all the surveyed genomes despite ancestral whole genome duplications has occurred. This indicates a possible deleterious gene dosage effect. Functional redundancy results in gene loss or neofunctionalization in different evolutionary lineages	Arabidopsis thaliana
evolution	eukaryal Pus10 genes share a conserved catalytic domain with archaeal Pus10 genes. Pus10 is found in earlier evolutionary branches of fungi (such as chytrid Batrachochytrium) but is absent in all dikaryon fungi surveyed (Ascomycetes and Basidiomycetes). Orthologs of Pus10, TrmA, and TruB are present in all the animals, plants, and protozoa surveyed. This indicates that the common eukaryotic ancestor possesses all the three genes. Pus10 exists as a single copy gene in all the surveyed genomes despite ancestral whole genome duplications has occurred. This indicates a possible deleterious gene dosage effect. Functional redundancy results in gene loss or neofunctionalization in different evolutionary lineages	Pyrococcus furiosus
metabolism	human Pus10 participates in apoptosis induced by the tumor necrosis factor-related apoptosis-inducing ligand	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)