Literature summary for 5.4.99.8 extracted from

Lodeiro, S.; Segura, M.J.R.; Stahl, M.; Schulz-Gasch, T.; Matsuda, S.P.T.
Oxidosqualene cyclase second-sphere residues profoundly influence the product profile (2004), ChemBioChem, 5, 1581-1585.

Search for more literature for 5.4.99.8

Cloned(Commentary)

Cloned (Comment)	Organism
mutants are expressed in Saccharomyces cerevisiae strain LHY4	Arabidopsis thaliana

Protein Variants

Protein Variants	Comment	Organism
H477N	produces 88% lanosterol and 12% parkeol	Arabidopsis thaliana
H477Q	produces 22% lanosterol, 73% parkeol, and 5% 9-beta-delta-7-lanosterol	Arabidopsis thaliana
I481V	produces 54% cycloartenol, 25% lanosterol, and 21% parkeol	Arabidopsis thaliana
Y410T	produces 65% lanosterol, 2% parkeol, and 33% 9-beta-delta-7-lanosterol	Arabidopsis thaliana
Y410T/H477N/I481V	produces 78% lanosterol and 22% 9-beta-delta-7-lanosterol	Arabidopsis thaliana
Y410T/H477Q/I481V	produces 78% lanosterol and 22% 9-beta-delta-7-lanosterol	Arabidopsis thaliana
Y410T/I481V	produces 78% lanosterol, less than 1% parkeol, and 22% 9-beta-delta-7-lanosterol	Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-2,3-oxidosqualene	Arabidopsis thaliana	-	cycloartenol	-	?

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	P38605	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-2,3-oxidosqualene	-	Arabidopsis thaliana	cycloartenol	-	?

Synonyms

Synonyms	Comment	Organism
cycloartenol synthase	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)