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Literature summary for 5.4.99.44 extracted from

  • Behm-Ansmant, I.; Branlant, C.; Motorin, Y.
    The Saccharomyces cerevisiae Pus2 protein encoded by YGL063w ORF is a mitochondrial tRNA:PSI27/28-synthase (2007), RNA, 13, 1641-1647.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
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Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion efficient and rapid targeting of Pus2p in yeast mitochondria Saccharomyces cerevisiae 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
mitochondrial tRNAArg(UCU) uridine27 Saccharomyces cerevisiae Pus2p is specifically dedicated to mitochondrial tRNA modification, the corresponding modification in cytoplasmic tRNAs is catalyzed by another protein (Pus1p). Pus2p does not catalyze pseudouridylation at position 72. Other pseudouridines in cytoplasmic yeast tRNA normally formed by Pus1p (positions 1, 34, 36, 65, 67) are absent in the mitochondrial compartment mitochondrial tRNAArg(UCU) pseudouridine27
-
?
mitochondrial tRNAArg(UCU) uridine27 Saccharomyces cerevisiae BY4742 Pus2p is specifically dedicated to mitochondrial tRNA modification, the corresponding modification in cytoplasmic tRNAs is catalyzed by another protein (Pus1p). Pus2p does not catalyze pseudouridylation at position 72. Other pseudouridines in cytoplasmic yeast tRNA normally formed by Pus1p (positions 1, 34, 36, 65, 67) are absent in the mitochondrial compartment mitochondrial tRNAArg(UCU) pseudouridine27
-
?
mitochondrial tRNALys(UUU) uridine28 Saccharomyces cerevisiae Pus2p is specifically dedicated to mitochondrial tRNA modification, the corresponding modification in cytoplasmic tRNAs is catalyzed by another protein (Pus1p). Pus2p does not catalyze pseudouridylation at position 72. Other pseudouridines in cytoplasmic yeast tRNA normally formed by Pus1p (positions 1, 34, 36, 65, 67) are absent in the mitochondrial compartment mitochondrial tRNALys(UUU) pseudouridine28
-
?
mitochondrial tRNALys(UUU) uridine28 Saccharomyces cerevisiae BY4742 Pus2p is specifically dedicated to mitochondrial tRNA modification, the corresponding modification in cytoplasmic tRNAs is catalyzed by another protein (Pus1p). Pus2p does not catalyze pseudouridylation at position 72. Other pseudouridines in cytoplasmic yeast tRNA normally formed by Pus1p (positions 1, 34, 36, 65, 67) are absent in the mitochondrial compartment mitochondrial tRNALys(UUU) pseudouridine28
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P53167
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Saccharomyces cerevisiae BY4742 P53167
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mitochondrial tRNAArg(UCU) uridine27 Pus2p is specifically dedicated to mitochondrial tRNA modification, the corresponding modification in cytoplasmic tRNAs is catalyzed by another protein (Pus1p). Pus2p does not catalyze pseudouridylation at position 72. Other pseudouridines in cytoplasmic yeast tRNA normally formed by Pus1p (positions 1, 34, 36, 65, 67) are absent in the mitochondrial compartment Saccharomyces cerevisiae mitochondrial tRNAArg(UCU) pseudouridine27
-
?
mitochondrial tRNAArg(UCU) uridine27 Pus2p is specifically dedicated to mitochondrial tRNA modification, the corresponding modification in cytoplasmic tRNAs is catalyzed by another protein (Pus1p). Pus2p does not catalyze pseudouridylation at position 72. Other pseudouridines in cytoplasmic yeast tRNA normally formed by Pus1p (positions 1, 34, 36, 65, 67) are absent in the mitochondrial compartment Saccharomyces cerevisiae BY4742 mitochondrial tRNAArg(UCU) pseudouridine27
-
?
mitochondrial tRNALys(UUU) uridine28 Pus2p is specifically dedicated to mitochondrial tRNA modification, the corresponding modification in cytoplasmic tRNAs is catalyzed by another protein (Pus1p). Pus2p does not catalyze pseudouridylation at position 72. Other pseudouridines in cytoplasmic yeast tRNA normally formed by Pus1p (positions 1, 34, 36, 65, 67) are absent in the mitochondrial compartment Saccharomyces cerevisiae mitochondrial tRNALys(UUU) pseudouridine28
-
?
mitochondrial tRNALys(UUU) uridine28 Pus2p is specifically dedicated to mitochondrial tRNA modification, the corresponding modification in cytoplasmic tRNAs is catalyzed by another protein (Pus1p). Pus2p does not catalyze pseudouridylation at position 72. Other pseudouridines in cytoplasmic yeast tRNA normally formed by Pus1p (positions 1, 34, 36, 65, 67) are absent in the mitochondrial compartment Saccharomyces cerevisiae BY4742 mitochondrial tRNALys(UUU) pseudouridine28
-
?

Synonyms

Synonyms Comment Organism
mitochondrial-specific tRNA:Psi-synthase
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Saccharomyces cerevisiae
Pus2 protein
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Saccharomyces cerevisiae
Pus2p
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Saccharomyces cerevisiae
tRNA:PSI27/28-synthase
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction disruption of the PUS2 gene leads to the absence of pseudouridine27 residues in the mitochondrial tRNAArg(UCU) and pseudouridine28 in the mitochondrial tRNALys(UUU) Saccharomyces cerevisiae