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Literature summary for 5.4.99.32 extracted from

  • Kimura, M.; Kushiro, T.; Shibuya, M.; Ebizuka, Y.; Abe, I.
    Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase (2010), Biochem. Biophys. Res. Commun., 391, 899-902.
    View publication on PubMed
Search for more literature for 5.4.99.32

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae strain GIL77 Aspergillus fumigatus

Protein Variants

Protein Variants Comment Organism
additional information an OSPC mutant in which the C-terminal residues 702APPGGMR708 are replaced with 702NKSCAIS708, no longer produces the protostadienol, but instead efficiently produces a 1:1 mixture of lanosterol and parkeol (oxidosqualene:lanosterol cyclase activity) Aspergillus fumigatus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Aspergillus fumigatus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
83090
-
 calculated from amino acid sequence Aspergillus fumigatus

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3S)-2,3-oxidosqualene
-
 Aspergillus fumigatus protosta-17(20)Z,24-dien-3beta-ol + (20R)-protosta-13(17),24-dien-3beta-ol 3:1 product ratio ?

Synonyms

Synonyms Comment Organism
OSC3
-
 Aspergillus fumigatus
OSPC
-
 Aspergillus fumigatus
oxidosqualene:protostadienol cyclase
-
 Aspergillus fumigatus