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Literature summary for 5.4.99.23 extracted from

  • Gutgsell, N.S.; Deutscher, M.P.; Ofengand, J.
    The pseudouridine synthase RluD is required for normal ribosome assembly and function in Escherichia coli (2005), RNA, 11, 1141-1152.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Synonyms

Synonyms Comment Organism
pseudouridine synthase RluD
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Escherichia coli
RluD
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Escherichia coli

General Information

General Information Comment Organism
malfunction loss of the RluD protein and its product pseudouridine residues (pseudouridine1911, pseudouridine 1915 and pseudouridine 1917) in a deletion strain lacking the rluD gene. This strain exhibits defects in ribosome assembly, biogenesis, and function. Specifically, there is a deficit of 70S ribosomes, an increase in 50S and 30S subunits, and the appearance of new 62S (derived from the breakdown of unstable 70S ribosomes) and 39S particles (immature precursors of the 50S subunits). The defect in ribosome assembly and resulting growth phenotype of the mutant could be restored by expression of wild-type RluD and synthesis of C1911, C1915, and C1917 residues, but not by catalytically inactive mutant RluD proteins, incapable of pseudouridine formation Escherichia coli