Literature summary for 5.4.99.2 extracted from

Mo, S.; Ban, Y.H.; Park, J.W.; Yoo, Y.J.; Yoon, Y.J.
Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor (2009), J. Ind. Microbiol. Biotechnol., 36, 1473-1482.

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Organism

Organism	UniProt	Comment	Textmining
Streptomyces clavuligerus	-	-	-
Streptomyces clavuligerus CKD1119	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(R)-2-methylmalonyl-CoA	-	Streptomyces clavuligerus	succinyl-CoA	-	?
(R)-2-methylmalonyl-CoA	-	Streptomyces clavuligerus CKD1119	succinyl-CoA	-	?

Synonyms

Synonyms	Comment	Organism
MCM	-	Streptomyces clavuligerus

Cofactor

Cofactor	Comment	Organism	Structure
adenosylcobalamin	-	Streptomyces clavuligerus

General Information

General Information	Comment	Organism
physiological function	the MCM pathway plays a key role in increasing the methylmalonyl-CoA pool for FK506 (tacrolimus) biosynthesis in Streptomyces clavuligerus CKD1119	Streptomyces clavuligerus

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Release 2023.1 (January 2023)