Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli JM 105 | Alicyclobacillus acidocaldarius |
Protein Variants | Comment | Organism |
---|---|---|
C25S/C50S/C435S/C455S/C537S | quintuple mutant | Alicyclobacillus acidocaldarius |
C25S/C50S/D376C/C435S/C455S/C537S | sextuple mutant | Alicyclobacillus acidocaldarius |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-dodecyliodoacetamide | IC50 wild-type >200 microMol, quintuple mutant >200 microMol, sextuple mutant >200 microMol, pH 6.0, 50°C | Alicyclobacillus acidocaldarius | |
N-squalenyliodoacetamide | IC50 wild-type >200 microMol, quintuple mutant >200 microMol, sextuple mutant 50 microMol, pH 6.0, 50°C | Alicyclobacillus acidocaldarius |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | squalene sextuple mutant: no activity | Alicyclobacillus acidocaldarius | |
0.001 | - |
(3S)-2,3-oxidosqualene | quintuple mutant, 50°C, pH 6.0 | Alicyclobacillus acidocaldarius | |
0.0015 | - |
(3S)-2,3-oxidosqualene | wild-type, 50°C, pH 6.0 | Alicyclobacillus acidocaldarius | |
0.0023 | - |
(3S)-2,3-oxidosqualene | sextuple mutant, 50°C, pH 6.0 | Alicyclobacillus acidocaldarius | |
0.01 | - |
squalene | quintuple mutant, 50°C, pH 6.0 | Alicyclobacillus acidocaldarius | |
0.0132 | - |
squalene | wild-type, 50°C, pH 6.0 | Alicyclobacillus acidocaldarius |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Alicyclobacillus acidocaldarius | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Alicyclobacillus acidocaldarius |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(3S)-2,3-oxidosqualene | - |
Alicyclobacillus acidocaldarius | lanosterol | - |
? | |
squalene | - |
Alicyclobacillus acidocaldarius | hopene | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SHC | - |
Alicyclobacillus acidocaldarius |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.05 | - |
IC50 sextuple mutant 50 microMol, pH 6.0, 50°C | Alicyclobacillus acidocaldarius | N-squalenyliodoacetamide | |
0.2 | - |
IC50 wild-type >200 microMol, quintuple mutant >200 microMol, sextuple mutant >200 microMol, pH 6.0, 50°C | Alicyclobacillus acidocaldarius | N-dodecyliodoacetamide | |
0.2 | - |
IC50 wild-type >200 microMol | Alicyclobacillus acidocaldarius | N-squalenyliodoacetamide | |
0.2 | - |
IC50 quintuple mutant >200 microMol | Alicyclobacillus acidocaldarius | N-squalenyliodoacetamide |