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Literature summary for 5.4.2.6 extracted from

  • Buckley, A.A.; Faustoferri, R.C.; Quivey, R.G.
    beta-Phosphoglucomutase contributes to aciduricity in Streptococcus mutans (2014), Microbiology, 160, 818-827.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.4.2.6

Cloned(Commentary)

Cloned (Comment) Organism
gene SMU.1747c or pgmB, DNA and amino acid sequence determination and analysis, genetic organization Streptococcus mutans

Protein Variants

Protein Variants Comment Organism
additional information generation and genetic complementation of the pgmB deletion MU1593 mutant strain, the mutant strain is acid-sensitive and exhibits reduced glycolytic output from glucose challenge. The fatty acid profile of MU1593 is altered compared with wild-type UA159 in all growth conditions tested Streptococcus mutans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24500
-
 x * 24500, about, sequence calculation Streptococcus mutans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-D-Glucose 1-phosphate Streptococcus mutans
-
 beta-D-Glucose 6-phosphate
-
 r
beta-D-Glucose 1-phosphate Streptococcus mutans UA159
-
 beta-D-Glucose 6-phosphate
-
 r

Organism

Organism UniProt Comment Textmining
Streptococcus mutans
-
 gene SMU.1747c or pgmB
-
Streptococcus mutans UA159
-
 gene SMU.1747c or pgmB
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information no difference in growth rate between wild-type strain UA159 and enzyme deletion mutant MU1593 during the exponential growth phase in medium buffered to pH 7.0 Streptococcus mutans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-D-Glucose 1-phosphate
-
 Streptococcus mutans beta-D-Glucose 6-phosphate
-
 r
beta-D-Glucose 1-phosphate
-
 Streptococcus mutans UA159 beta-D-Glucose 6-phosphate
-
 r

Subunits

Subunits Comment Organism
? x * 24500, about, sequence calculation Streptococcus mutans

General Information

General Information Comment Organism
malfunction deletion of pgmB affects known virulence factors of Streptococcus mutans, specifically acid tolerance, mutant strain MU1593 is defective in its acid-responsiveness. The DELTApgmB strain shows a decreased ability to survive acid challenge. Additionally, the strain lacking beta-phosphoglucomutase has a diminished glycolytic profile compared with the parental strain. Proton permeability is increased in strain MU1593. Deletion of pgmB has a negative impact on the virulence of Streptococcus mutans in the Galleria mellonella (greater wax worm) animal model. Phenotype of strain MU1593, overview Streptococcus mutans
physiological function The enzyme plays a role at the juncture of carbohydrate metabolism and virulence. beta-Phosphoglucomutase contributes to aciduricity in Streptococcus mutans Streptococcus mutans