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Literature summary for 5.4.2.3 extracted from

  • Mariappa, D.; Sauert, K.; Marino, K.; Turnock, D.; Webster, R.; van Aalten, D.M.; Ferguson, M.A.; Mueller, H.A.
    Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila (2011), Sci. Signal., 4, ra89.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.4.2.3

Cloned(Commentary)

Cloned (Comment) Organism
gene nst, DNA and amino acid sequence determination, gene nst is allelic to CG10627, expression analysis Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Drosophila melanogaster 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-D-glucosamine 6-phosphate Drosophila melanogaster
-
 N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VTZ4 gene nst
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Drosophila melanogaster
-
fibroblast
-
 Drosophila melanogaster
-
mesoderm
-
 Drosophila melanogaster
-
trachea
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-D-glucosamine 6-phosphate
-
 Drosophila melanogaster N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r

Synonyms

Synonyms Comment Organism
PGM3
-
 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction loss-of-function mutations in the nst gene, which encodes PGM3, block fibroblast growth factor signaling during embryonic mesoderm and tracheal development. In nst mutants with an 80% reduction in the amount of UDP-GlcNAc, O-GlcNAcylation is compromised. Embryos maternally and zygotically mutant for nst exhibit defects in mesoderm layer formation during gastrulation that are similar to those observed in embryos with mutations in the gene encoding the fibroblast growth factor receptor Heartless (Htl). Zygotic nst mutants (nstZ) exhibit normal dorsal mesoderm differentiation, embryos homozygous for the hypomorphic htlYY262 allele show a reduction in dorsal mesoderm. Phenotypes, overview. Dof is the critical component in MAPK activation affected in nst mutants Drosophila melanogaster
metabolism Nst acts downstream of fibroblast growth factor receptor signaling Drosophila melanogaster
physiological function the enzyme is required for normal cellular levels of UDP-GlcNAc and essential in UDP-GlcNAc biosynthesis, and for fibroblast growth factor signaling in early embryos. Role for Nst in fibroblast growth factor receptor Heartless (Htl) signaling Drosophila melanogaster