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Literature summary for 5.4.2.2 extracted from

  • Felek, S.; Muszynski, A.; Carlson, R.W.; Tsang, T.M.; Hinnebusch, B.J.; Krukonis, E.S.
    Phosphoglucomutase of Yersinia pestis is required for autoaggregation and polymyxin B resistance (2010), Infect. Immun., 78, 1163-1175.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.4.2.2

Organism

Organism UniProt Comment Textmining
Yersinia pestis
-
-
-
Yersinia pestis KIM5
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-D-glucose 1-phosphate
-
 Yersinia pestis alpha-D-glucose 6-phosphate
-
 ?
alpha-D-glucose 1-phosphate
-
 Yersinia pestis KIM5 alpha-D-glucose 6-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PGM
-
 Yersinia pestis
PgmA
-
 Yersinia pestis

General Information

General Information Comment Organism
malfunction targeted deletion of pgmA in Yersinia pestis strain KIM5 results in loss of autoaggregation, the deletion mutant displays more than 1000fold increased sensitivity to polymyxin B compared to the parental strain Yersinia pestis
physiological function PgmA is required for efficient autoaggregation in Yersinia pestis and plays an important role in antimicrobial peptide resistance Yersinia pestis