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Literature summary for 5.4.2.12 extracted from

  • Chander, M.; Setlow, B.; Setlow, P.
    The enzymatic activity of phosphoglycerate mutase from gram-positive endospore-forming bacteria requires Mn2+ and is pH sensitive (1998), Can. J. Microbiol., 44, 759-767.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Sodium metavanadate 0.01 mM and 0.1 mM, 50% and 90% inhibition of phosphoglycerate mutase activity, respectively Streptomyces coelicolor

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6
-
3-phospho-D-glycerate 25°C, pH 6.0 Bacillus subtilis
4.2
-
3-phospho-D-glycerate 25°C, pH 7.0 Clostridium perfringens
4.4
-
3-phospho-D-glycerate 25°C, pH 7.0 Bacillus subtilis
4.9
-
3-phospho-D-glycerate 25°C, pH 8.0 Bacillus subtilis
4.9
-
3-phospho-D-glycerate 25°C, pH 8.0 Clostridium perfringens
5.2
-
3-phospho-D-glycerate 25°C, pH 6.0 Clostridium perfringens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 1 mm, 19% of activity with 0.5 mM Mn2+ Staphylococcus saprophyticus
Co2+ required for activity, 2fold higher activity at 0.4 mM than with 0.5 mM Mn2+ Clostridium perfringens
Mn2+ required for activity Bacillus subtilis
Mn2+ required for activity Clostridium perfringens
Mn2+ required for activity Staphylococcus saprophyticus
Mn2+ required for activity Sporosarcina ureae
Mn2+ required for activity Planococcus citreus
additional information no metal ions required for activity Micrococcus luteus
additional information no metal ions required for activity Streptomyces coelicolor

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-phospho-D-glycerate Bacillus subtilis
-
3-phospho-D-glycerate
-
r
2-phospho-D-glycerate Micrococcus luteus
-
3-phospho-D-glycerate
-
r
2-phospho-D-glycerate Streptomyces coelicolor
-
3-phospho-D-glycerate
-
r
2-phospho-D-glycerate Clostridium perfringens
-
3-phospho-D-glycerate
-
r
2-phospho-D-glycerate Staphylococcus saprophyticus
-
3-phospho-D-glycerate
-
r
2-phospho-D-glycerate Sporosarcina ureae
-
3-phospho-D-glycerate
-
r
2-phospho-D-glycerate Planococcus citreus
-
3-phospho-D-glycerate
-
r

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Clostridium perfringens
-
-
-
Micrococcus luteus
-
-
-
Planococcus citreus
-
-
-
Sporosarcina ureae
-
-
-
Staphylococcus saprophyticus
-
-
-
Streptomyces coelicolor
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partialy purified Bacillus subtilis
partialy purified Micrococcus luteus
partialy purified Streptomyces coelicolor
partialy purified Clostridium perfringens
partialy purified Staphylococcus saprophyticus
partialy purified Sporosarcina ureae
partialy purified Planococcus citreus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.003
-
-
Sporosarcina ureae
0.014
-
-
Bacillus subtilis
0.1
-
-
Staphylococcus saprophyticus
0.24
-
-
Clostridium perfringens
0.49
-
-
Micrococcus luteus
0.93
-
-
Streptomyces coelicolor
1
-
-
Planococcus citreus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phospho-D-glycerate
-
Bacillus subtilis 3-phospho-D-glycerate
-
r
2-phospho-D-glycerate
-
Micrococcus luteus 3-phospho-D-glycerate
-
r
2-phospho-D-glycerate
-
Streptomyces coelicolor 3-phospho-D-glycerate
-
r
2-phospho-D-glycerate
-
Clostridium perfringens 3-phospho-D-glycerate
-
r
2-phospho-D-glycerate
-
Staphylococcus saprophyticus 3-phospho-D-glycerate
-
r
2-phospho-D-glycerate
-
Sporosarcina ureae 3-phospho-D-glycerate
-
r
2-phospho-D-glycerate
-
Planococcus citreus 3-phospho-D-glycerate
-
r

Synonyms

Synonyms Comment Organism
PGM
-
Bacillus subtilis
PGM
-
Micrococcus luteus
PGM
-
Streptomyces coelicolor
PGM
-
Clostridium perfringens
PGM
-
Staphylococcus saprophyticus
PGM
-
Sporosarcina ureae
PGM
-
Planococcus citreus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Bacillus subtilis
8
-
-
Micrococcus luteus
8
-
-
Streptomyces coelicolor
8
-
-
Clostridium perfringens
8
-
-
Staphylococcus saprophyticus
8
-
-
Sporosarcina ureae
8
-
-
Planococcus citreus

pH Range

pH Minimum pH Maximum Comment Organism
6 8 1% and 18% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively Sporosarcina ureae
6 8 1.7% and 19% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively Planococcus citreus
6 8 24% and 36% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively Bacillus subtilis
6 8 3.1% and 21% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively Staphylococcus saprophyticus
6 8 7.3% and 39% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively, inhibition at low pH is reversed by elevating the pH Clostridium perfringens
6 8 little change in activity between pH 6.0 and pH 8.0 Micrococcus luteus
6 8 little change in activity between pH 6.0 and pH 8.0 Streptomyces coelicolor

Cofactor

Cofactor Comment Organism Structure
additional information 2,3-bisphosphoglycerate independent phosphoglycerate mutase Bacillus subtilis
additional information 2,3-bisphosphoglycerate independent phosphoglycerate mutase Micrococcus luteus
additional information 2,3-bisphosphoglycerate independent phosphoglycerate mutase Streptomyces coelicolor
additional information 2,3-bisphosphoglycerate independent phosphoglycerate mutase Clostridium perfringens
additional information 2,3-bisphosphoglycerate independent phosphoglycerate mutase Staphylococcus saprophyticus
additional information 2,3-bisphosphoglycerate independent phosphoglycerate mutase Sporosarcina ureae
additional information 2,3-bisphosphoglycerate independent phosphoglycerate mutase Planococcus citreus