Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Sodium metavanadate | 0.01 mM and 0.1 mM, 50% and 90% inhibition of phosphoglycerate mutase activity, respectively | Streptomyces coelicolor |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3.6 | - |
3-phospho-D-glycerate | 25°C, pH 6.0 | Bacillus subtilis | |
4.2 | - |
3-phospho-D-glycerate | 25°C, pH 7.0 | Clostridium perfringens | |
4.4 | - |
3-phospho-D-glycerate | 25°C, pH 7.0 | Bacillus subtilis | |
4.9 | - |
3-phospho-D-glycerate | 25°C, pH 8.0 | Bacillus subtilis | |
4.9 | - |
3-phospho-D-glycerate | 25°C, pH 8.0 | Clostridium perfringens | |
5.2 | - |
3-phospho-D-glycerate | 25°C, pH 6.0 | Clostridium perfringens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 1 mm, 19% of activity with 0.5 mM Mn2+ | Staphylococcus saprophyticus | |
Co2+ | required for activity, 2fold higher activity at 0.4 mM than with 0.5 mM Mn2+ | Clostridium perfringens | |
Mn2+ | required for activity | Bacillus subtilis | |
Mn2+ | required for activity | Clostridium perfringens | |
Mn2+ | required for activity | Staphylococcus saprophyticus | |
Mn2+ | required for activity | Sporosarcina ureae | |
Mn2+ | required for activity | Planococcus citreus | |
additional information | no metal ions required for activity | Micrococcus luteus | |
additional information | no metal ions required for activity | Streptomyces coelicolor |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-phospho-D-glycerate | Bacillus subtilis | - |
3-phospho-D-glycerate | - |
r | |
2-phospho-D-glycerate | Micrococcus luteus | - |
3-phospho-D-glycerate | - |
r | |
2-phospho-D-glycerate | Streptomyces coelicolor | - |
3-phospho-D-glycerate | - |
r | |
2-phospho-D-glycerate | Clostridium perfringens | - |
3-phospho-D-glycerate | - |
r | |
2-phospho-D-glycerate | Staphylococcus saprophyticus | - |
3-phospho-D-glycerate | - |
r | |
2-phospho-D-glycerate | Sporosarcina ureae | - |
3-phospho-D-glycerate | - |
r | |
2-phospho-D-glycerate | Planococcus citreus | - |
3-phospho-D-glycerate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | - |
- |
- |
Clostridium perfringens | - |
- |
- |
Micrococcus luteus | - |
- |
- |
Planococcus citreus | - |
- |
- |
Sporosarcina ureae | - |
- |
- |
Staphylococcus saprophyticus | - |
- |
- |
Streptomyces coelicolor | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partialy purified | Bacillus subtilis |
partialy purified | Micrococcus luteus |
partialy purified | Streptomyces coelicolor |
partialy purified | Clostridium perfringens |
partialy purified | Staphylococcus saprophyticus |
partialy purified | Sporosarcina ureae |
partialy purified | Planococcus citreus |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.003 | - |
- |
Sporosarcina ureae |
0.014 | - |
- |
Bacillus subtilis |
0.1 | - |
- |
Staphylococcus saprophyticus |
0.24 | - |
- |
Clostridium perfringens |
0.49 | - |
- |
Micrococcus luteus |
0.93 | - |
- |
Streptomyces coelicolor |
1 | - |
- |
Planococcus citreus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-phospho-D-glycerate | - |
Bacillus subtilis | 3-phospho-D-glycerate | - |
r | |
2-phospho-D-glycerate | - |
Micrococcus luteus | 3-phospho-D-glycerate | - |
r | |
2-phospho-D-glycerate | - |
Streptomyces coelicolor | 3-phospho-D-glycerate | - |
r | |
2-phospho-D-glycerate | - |
Clostridium perfringens | 3-phospho-D-glycerate | - |
r | |
2-phospho-D-glycerate | - |
Staphylococcus saprophyticus | 3-phospho-D-glycerate | - |
r | |
2-phospho-D-glycerate | - |
Sporosarcina ureae | 3-phospho-D-glycerate | - |
r | |
2-phospho-D-glycerate | - |
Planococcus citreus | 3-phospho-D-glycerate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
PGM | - |
Bacillus subtilis |
PGM | - |
Micrococcus luteus |
PGM | - |
Streptomyces coelicolor |
PGM | - |
Clostridium perfringens |
PGM | - |
Staphylococcus saprophyticus |
PGM | - |
Sporosarcina ureae |
PGM | - |
Planococcus citreus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Bacillus subtilis |
8 | - |
- |
Micrococcus luteus |
8 | - |
- |
Streptomyces coelicolor |
8 | - |
- |
Clostridium perfringens |
8 | - |
- |
Staphylococcus saprophyticus |
8 | - |
- |
Sporosarcina ureae |
8 | - |
- |
Planococcus citreus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 8 | 1% and 18% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively | Sporosarcina ureae |
6 | 8 | 1.7% and 19% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively | Planococcus citreus |
6 | 8 | 24% and 36% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively | Bacillus subtilis |
6 | 8 | 3.1% and 21% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively | Staphylococcus saprophyticus |
6 | 8 | 7.3% and 39% of maximal activity at pH 6.0 and pH 7.0 in the presence of 1 mM and 0.5 mM Mn2+, respectively, inhibition at low pH is reversed by elevating the pH | Clostridium perfringens |
6 | 8 | little change in activity between pH 6.0 and pH 8.0 | Micrococcus luteus |
6 | 8 | little change in activity between pH 6.0 and pH 8.0 | Streptomyces coelicolor |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | 2,3-bisphosphoglycerate independent phosphoglycerate mutase | Bacillus subtilis | |
additional information | 2,3-bisphosphoglycerate independent phosphoglycerate mutase | Micrococcus luteus | |
additional information | 2,3-bisphosphoglycerate independent phosphoglycerate mutase | Streptomyces coelicolor | |
additional information | 2,3-bisphosphoglycerate independent phosphoglycerate mutase | Clostridium perfringens | |
additional information | 2,3-bisphosphoglycerate independent phosphoglycerate mutase | Staphylococcus saprophyticus | |
additional information | 2,3-bisphosphoglycerate independent phosphoglycerate mutase | Sporosarcina ureae | |
additional information | 2,3-bisphosphoglycerate independent phosphoglycerate mutase | Planococcus citreus |