Literature summary for 5.4.2.11 extracted from

Rigden, D.J.; Walter, R.A.; Phillips, S.E.; Fothergill-Gilmore, L.A.
Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis (1999), J. Mol. Biol., 289, 691-699.

Search for more literature for 5.4.2.11

Activating Compound

Activating Compound	Comment	Organism	Structure
2,3-bisphosphoglycerate	-	Schizosaccharomyces pombe
2,3-bisphosphoglycerate	-	Saccharomyces cerevisiae

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystallization of PGAM complexed with inositol hexakisphosphate and benzene hexacarboxylate, crystal structures at 2.5-2.8 A resolution	Saccharomyces cerevisiae

General Stability

General Stability	Organism
little effect of the protease thermolysin on enzyme activity	Schizosaccharomyces pombe

Inhibitors

Inhibitors	Comment	Organism	Structure
benzene hexacarboxylate	-	Saccharomyces cerevisiae
benzene hexacarboxylate	-	Schizosaccharomyces pombe
benzene-1,2,3-tricarboxylate	-	Saccharomyces cerevisiae
benzene-1,2,3-tricarboxylate	-	Schizosaccharomyces pombe
benzene-1,2,4,5-tetracarboxylate	-	Saccharomyces cerevisiae
benzene-1,2,4,5-tetracarboxylate	-	Schizosaccharomyces pombe
benzene-1,2,4-tricarboxylate	-	Saccharomyces cerevisiae
benzene-1,2,4-tricarboxylate	-	Schizosaccharomyces pombe
benzene-1,3,5-tricarboxylate	-	Saccharomyces cerevisiae
benzene-1,3,5-tricarboxylate	-	Schizosaccharomyces pombe
Inositol hexakisphosphate	-	Saccharomyces cerevisiae
Inositol hexakisphosphate	-	Schizosaccharomyces pombe

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.56	-	3-phosphoglycerate	-	Saccharomyces cerevisiae
0.58	-	3-phosphoglycerate	-	Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-phospho-D-glycerate	Schizosaccharomyces pombe	-	3-phospho-D-glycerate	-	r
2-phospho-D-glycerate	Saccharomyces cerevisiae	-	3-phospho-D-glycerate	-	r

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P00950	-	-
Schizosaccharomyces pombe	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Schizosaccharomyces pombe
-	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-phospho-D-glycerate	-	Schizosaccharomyces pombe	3-phospho-D-glycerate	-	r
2-phospho-D-glycerate	-	Saccharomyces cerevisiae	3-phospho-D-glycerate	-	r
3-Phosphoglycerate	-	Schizosaccharomyces pombe	2-Phosphoglycerate	-	?

Synonyms

Synonyms	Comment	Organism
PGAM	-	Schizosaccharomyces pombe
PGAM	-	Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
82	-	3-phospho-D-glycerate	-	Schizosaccharomyces pombe
530	-	3-phosphoglycerate	-	Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.004	-	Inositol hexakisphosphate	-	Saccharomyces cerevisiae
0.006	-	benzene hexacarboxylate	-	Saccharomyces cerevisiae
0.013	-	benzene-1,2,4,5-tetracarboxylate	-	Saccharomyces cerevisiae
0.021	-	benzene-1,2,4-tricarboxylate	-	Saccharomyces cerevisiae
0.022	-	benzene hexacarboxylate	-	Schizosaccharomyces pombe
0.023	-	benzene-1,2,3-tricarboxylate	-	Saccharomyces cerevisiae
0.024	-	benzene-1,3,5-tricarboxylate	-	Saccharomyces cerevisiae
0.035	-	Inositol hexakisphosphate	-	Schizosaccharomyces pombe
0.053	-	benzene-1,3,5-tricarboxylate	-	Schizosaccharomyces pombe
0.055	-	benzene-1,2,4,5-tetracarboxylate	-	Schizosaccharomyces pombe
0.062	-	benzene-1,2,4-tricarboxylate	-	Schizosaccharomyces pombe
0.067	-	benzene-1,2,3-tricarboxylate	-	Schizosaccharomyces pombe

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)