Literature summary for 5.4.2.11 extracted from

Rigden, D.J.; Walter, R.A.; Phillips, S.E.; Fothergill-Gilmore, L.A.
Sulphate ions observed in the 2.12 A structure of a new crystal form of S. cerevisiae phosphoglycerate mutase provide insights into understanding the catalytic mechanism (1999), J. Mol. Biol., 286, 1507-1517.

Search for more literature for 5.4.2.11

Activating Compound

Activating Compound	Comment	Organism	Structure
2,3-bisphosphoglycerate	-	Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression in Saccharomyces cerevisae	Saccharomyces cerevisiae

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure at 2.12 a resolution	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
A60S	69% of wild-type activity	Saccharomyces cerevisiae
E86Q	1% of wild-type activity	Saccharomyces cerevisiae
S11A	4% of wild-type activity	Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.43	-	3-phospho-D-glycerate	A60S mutant	Saccharomyces cerevisiae
0.47	-	3-phospho-D-glycerate	-	Saccharomyces cerevisiae
0.71	-	3-phospho-D-glycerate	S11A mutant	Saccharomyces cerevisiae
1.1	-	3-phospho-D-glycerate	E86Q mutant	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-phospho-D-glycerate	Saccharomyces cerevisiae	-	3-phospho-D-glycerate	-	r

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P00950	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-phospho-D-glycerate	-	Saccharomyces cerevisiae	3-phospho-D-glycerate	-	r

Synonyms

Synonyms	Comment	Organism
PGAM	-	Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
4.7	-	3-phospho-D-glycerate	E86Q mutant	Saccharomyces cerevisiae
20	-	3-phospho-D-glycerate	S11A mutant	Saccharomyces cerevisiae
370	-	3-phospho-D-glycerate	A60S mutant	Saccharomyces cerevisiae
530	-	3-phospho-D-glycerate	-	Saccharomyces cerevisiae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)