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Literature summary for 5.3.99.5 extracted from
- The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer (2010), Biochim. Biophys. Acta, 1805, 153-166.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ozagrel | - |
Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prostaglandin H2 | Homo sapiens | - |
thromboxane A2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| breast carcinoma cell | - |
Homo sapiens | - |
| colorectal cancer cell | - |
Homo sapiens | - |
| lung | in normal lung tissue, TXS is moderately expressed in bronchial epithelial cells and weakly expressed in vascular smooth muscle cells | Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
| non-small cell lung cancer cell | - |
Homo sapiens | - |
| papillary thyroid carcinoma cell | - |
Homo sapiens | - |
| prostate cancer cell | - |
Homo sapiens | - |
| renal carcinoma cell | - |
Homo sapiens | - |
| urinary bladder cancer cell | - |
Homo sapiens | - |
| uterine cancer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prostaglandin H2 | - |
Homo sapiens | thromboxane A2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thromboxane A2 synthase | - |
Homo sapiens |
| TXS | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Homo sapiens | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | an overall increase in TXS expression is observed in tumor tissues relative to normal, increased TXS expression at mRNA level is reported in renal cell carcinoma, breast carcinoma, prostate cancer and uterine cancer when compared with matched normal tissues | up |
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Release 2023.1 (January 2023)
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